Guatemala's President Alejandro Giammattei escaped unharmed after an armed attack on his entourage in the northwest of the country, local media reported on Sunday.
Several people were injured after unidentified gunmen opened fire at Giammattei's delegation in the Huehuetenango city on Saturday, officials said.
Clashes took place between the military escort guarding the president's entourage and the assailants.
A large-scale investigation was launched into the attack.
"We inform the people of Guatemala and the international community that the president is unharmed and was evacuated from the area in a timely manner," a government statement said.
One of the gunmen, who is Mexican, was injured in the confrontation, the statement said. The others fled in the car towards the Mexican border about 80 km (50 miles) away, it said.
Four Guatemalans were later detained by the Mexican military, the Guatemalan government said. Two rifle grenades were also found over the border in Mexico.
A press representative for Mexico's Secretariat of National Defense (Sedena) did not immediately respond to a request for comment.By Rabiu Olugbenga